abstract：:The inflammatory response plays an important role during the induction of several neonatal diseases. Previous studies have shown that during newborn infections, the natural imbalance between pro- and anti-inflammatory responses shifts toward the production of pro-inflammatory cytokines. In this study, we employed an a...

journal_title：Immunology letters

authors： Antas PR,Pedro TQ,Santiago EA,Lima JR,Silva FC,Melca LA,Ponte CG

更新日期：2016-02-01 00:00:00

abstract：:Common γ chain (γC) cytokines, namely IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 are important for the proliferation, differentiation, and survival of lymphocytes that display antitumor activity, thus stimulating considerable interest for the use of cytokines in cancer immunotherapy. In this review, we will focus on the...

journal_title：Immunology letters

authors： Pulliam SR,Uzhachenko RV,Adunyah SE,Shanker A

更新日期：2016-01-01 00:00:00

abstract：:Indoleamine 2,3-dioxygenase (IDO) is an enzyme with an immunosuppressive effect whose function is diverted by tumor cells to counteract immune cell functions, inducing immune escape of tumor cells. The aim of this study was to investigate the clinical significance of IDO in nasopharyngeal carcinoma (NPC). Compared to ...

journal_title：Immunology letters

authors： Ben-Haj-Ayed A,Moussa A,Ghedira R,Gabbouj S,Miled S,Bouzid N,Tebra-Mrad S,Bouaouina N,Chouchane L,Zakhama A,Hassen E

更新日期：2016-01-01 00:00:00

abstract：:Activation of the NF-κB pathway is causally linked to initiation and progression of diverse cancers. Therefore, IKKβ, the key regulatory kinase of the canonical NF-κB pathway, should be a logical target for cancer treatment. However, existing IKKβ inhibitors are known to induce paradoxical immune activation, which lim...

journal_title：Immunology letters

authors： Maroni D,Rana S,Mukhopadhyay C,Natarajan A,Naramura M

更新日期：2015-12-01 00:00:00

abstract：:Bisphenol A (BPA) is a widely used plasticizer, which came into focus because of its genotoxic and sensitizing potential. Besides its toxic properties, BPA is also well-known for its antioxidant chemical properties. This in vitro study investigated the interference of BPA with interferon-γ (IFN-γ)-induced tryptophan b...

journal_title：Immunology letters

authors： Gostner JM,Raggl E,Becker K,Überall F,Schennach H,Pease JE,Fuchs D

更新日期：2015-12-01 00:00:00

abstract：:The expression level of complement regulators in ovarian and corpus uteri tumors was not fully established so far. In current manuscript we performed gene expression analysis by the real-time PCR approach to investigate both membrane bound - CD55 and CD59 and fluid phase - factor H and factor H-like 1 complement regul...

journal_title：Immunology letters

authors： Kapka-Skrzypczak L,Wolinska E,Szparecki G,Wilczynski GM,Czajka M,Skrzypczak M

更新日期：2015-10-01 00:00:00

abstract：:Using micro-electrode technique we studied the effects of interleukin-2 (50 ng/ml) on bio-electric activity of rat atrial myocardium under normal conditions and after gradual stretching of the tissue. It was shown that interleukin-2 caused increasing in the duration of action potential at the levels of 25, 50, and 90%...

journal_title：Immunology letters

authors： Aksyonov A,Mitrokhin VM,Mladenov MI

更新日期：2015-09-01 00:00:00

abstract：:Coenzyme Q10 (CoQ10) is a lipid-soluble antioxidant synthesized in human body. This enzyme promotes immune system function and can be used as a dietary supplement. Rheumatoid arthritis (RA) is an autoimmune disease leading to chronic joint inflammation. RA results in severe destruction of cartilage and disability. Thi...

journal_title：Immunology letters

authors： Jhun J,Lee SH,Byun JK,Jeong JH,Kim EK,Lee J,Jung YO,Shin D,Park SH,Cho ML

更新日期：2015-08-01 00:00:00

abstract：:Interleukin-33 is an IL-1 family cytokine which signals via its T1/ST2 receptor, and acts as a key regulator of inflammation. This study aims to measure the expression of soluble ST2 (sST2) and IL-33 in endometriosis. We investigated thirty women with laparoscopic and histopathological confirmed endometriosis and 20 c...

journal_title：Immunology letters

authors： Mbarik M,Kaabachi W,Henidi B,Sassi FH,Hamzaoui K

更新日期：2015-07-01 00:00:00

abstract：:The human matrix metalloproteinases (MMPs) are importantly involved in aneurysm formation. Since the clinical manifestations in Behçet disease (BD) include aneurysm formation among major symptoms, polymorphisms in MMP-9 might be associated with BD susceptibility. The aim of the current case-control study was to invest...

journal_title：Immunology letters

authors： Naouali A,Kaabachi W,Tizaoui K,Amor AB,Hamzaoui A,Hamzaoui K

更新日期：2015-03-01 00:00:00

abstract：:Colonization with Streptococcus pneumoniae (S. pneumoniae) is associated with an increased risk for recurrent wheeze and asthma. Killed S. pneumoniae showed some potential as an effective immunomodulatory therapy in a murine model of asthma. Murine studies demonstrated protection against allergic asthma by symbiotic b...

journal_title：Immunology letters

authors： Hartmann C,Behrendt AK,Henken S,Wölbeling F,Maus UA,Hansen G

更新日期：2015-03-01 00:00:00

abstract：:Interleukin-21 (IL-21) is a T cell-derived cytokine modulating T cell, B cell, and natural killer cell responses. To determine whether IL-21 contributes to pathologic processes, recombinant IL-21 receptor (R) fusion protein (rhIL-21R-Fc) was examined in mice models of autoimmune arthritis (collagen-induced arthritis)....

journal_title：Immunology letters

authors： Ryu JG,Lee J,Kim EK,Seo HB,Park JS,Lee SY,Moon YM,Yoo SH,Park YW,Park SH,Cho ML,Kim HY

更新日期：2015-02-01 00:00:00

abstract：:Crohn's disease and ulcerative colitis, known together as inflammatory bowel disease (IBD), are severe autoimmune disorders now causing gut inflammation and ulceration, among other symptoms, in up to 1 in 250 people worldwide. Incidence and prevalence of IBD have been increasing dramatically over the past several deca...

journal_title：Immunology letters

authors： Huang H,Vangay P,McKinlay CE,Knights D

更新日期：2014-12-01 00:00:00

abstract：:Clinical immunology is in the Netherlands a separate clinical specialty within internal medicine and pediatrics. Clinical immunologists work closely together with nephrologists, rheumatologists and many other medical specialists. Apart from research and teaching, clinical immunologists are taking care of patients with...

journal_title：Immunology letters

authors： Tervaert JW,Kallenberg CG

更新日期：2014-12-01 00:00:00

abstract：:Immunodeficiencies can lead to alterations of the gut microbiome that render it pathogenic and capable of transmitting disease to naïve hosts. Here, we review the role of Toll-like receptor (TLR) 5, the innate receptor for bacterial flagellin, in immune responses to the normal gut microbiota with a focus its role on a...

journal_title：Immunology letters

authors： Leifer CA,McConkey C,Li S,Chassaing B,Gewirtz AT,Ley RE

更新日期：2014-12-01 00:00:00

abstract：:The basic functions of the immune system are protection from pathogens and maintenance of tolerance to self. The maintenance of commensal microbiota at mucosal surfaces adds a layer of complexity to these basic functions. Recent reports suggest follicular helper T cells (Tfh), a CD4(+) T cell subset specialized to pro...

journal_title：Immunology letters

authors： Winstead CJ

更新日期：2014-12-01 00:00:00

abstract：:This study was to investigate the role of macrophage migration inhibitory factor (MIF) in mouse acute otitis media (AOM), we hypothesize that blocking MIF activity will relieve mouse AOM. A mouse AOM model was constructed by injecting lipopolysaccharide (LPS) into the middle ear of C57BL/6 mice through the tympanic me...

journal_title：Immunology letters

authors： Zhang J,Xu M,Zheng Q,Zhang Y,Ma W,Zhang Z

更新日期：2014-11-01 00:00:00

abstract：:As a cytokine adjuvant, granulocyte-macrophage colony-stimulating factor (GM-CSF) has been demonstrated to play central roles in the enhancement of the immune response and protection elicited by experimental vaccines. However, in our previous work, the co-administration of GM-CSF produced untoward effects on the immun...

journal_title：Immunology letters

authors： Chen H,Gao N,Wu J,Zheng X,Li J,Fan D,An J

更新日期：2014-11-01 00:00:00

abstract：:Wnt5a is a secreted pleiotropic glycoprotein produced in an inflammatory state by a wide spectrum of ubiquitous cell populations. Recently, we demonstrated that Wnt5a skews the differentiation of human monocyte derived dendritic cells (moDCs) to a tolerogenic functional state. In this study we focus our interest on th...

journal_title：Immunology letters

authors： Valencia J,Martínez VG,Hidalgo L,Hernández-López C,Canseco NM,Vicente A,Varas A,Sacedón R

更新日期：2014-11-01 00:00:00

abstract：:Aging is associated to dysfunctional changes in the immune system, a process termed immunosenescence. Elderly individuals usually present chronic low level inflammation, likely as the consequence of continued exposure to antigens combined with poor immune function, increases in production of pro-inflammatory cytokines...

journal_title：Immunology letters

authors： Campos C,Pera A,Lopez-Fernandez I,Alonso C,Tarazona R,Solana R

更新日期：2014-11-01 00:00:00

abstract：:Interleukin-35 (IL-35) is a novel anti-inflammatory cytokine and has been shown to play an important role in maintaining immune homeostasis. However, the effect of IL-35 on human asthma remains unclear. The present study is to investigate the expression and significance of IL-35 in childhood asthma. Forty-one asthmati...

journal_title：Immunology letters

authors： Ma Y,Liu X,Wei Z,Wang X,Xu D,Dai S,Li Y,Gao M,Ji C,Guo C,Zhang L,Wang X

更新日期：2014-11-01 00:00:00

abstract：:Many alterations of innate and adaptive immunity are common in the aging population, which reflect a deterioration of the immune system, and have lead to the terms "immune aging" or "immunosenescence". Systems Biology aims to the comprehensive knowledge of the structure, dynamics, control and design that define a give...

journal_title：Immunology letters

authors： O'Connor JE,Herrera G,Martínez-Romero A,de Oyanguren FS,Díaz L,Gomes A,Balaguer S,Callaghan RC

更新日期：2014-11-01 00:00:00

abstract：:Establishment and maintenance of pregnancy represents a challenge for the maternal immune system since it has to defend against pathogens and tolerate paternal alloantigens expressed in fetal tissues. Regulatory T (Treg) cells, a subset of suppressor CD4(+) T cells, play a dominant role in the maintenance of immunolog...

journal_title：Immunology letters

authors： La Rocca C,Carbone F,Longobardi S,Matarese G

更新日期：2014-11-01 00:00:00

abstract：:In early seventies "natural killer (NK) cells", a third lymphocyte subset was discovered that revealed an unexpected ability to kill syngeneic and allogeneic tumor targets, thus emerging as the most potent non-specific cytotoxic cells in both human and mouse. Decades of research revealed the multifaceted nature of the...

journal_title：Immunology letters

authors： Bellora F,Castriconi R,Dondero A,Carrega P,Mantovani A,Ferlazzo G,Moretta A,Bottino C

更新日期：2014-10-01 00:00:00

abstract：:Tuberculosis (TB) is a leading cause of global mortality due to infectious diseases. Expression of cyclooxygenase-2 (COX-2) acts as an important influencing factor favoring bacillary survival during TB infection. In this study, we investigated the Mycobacterium tuberculosis proteins recognized by sera from TB patient ...

journal_title：Immunology letters

authors： Zhao JW,Sun ZQ,Zhang XY,Zhang Y,Liu J,Ye J,Chen CC,Samten B,Wang HH,Guo XK,Zhang SL

更新日期：2014-09-01 00:00:00

abstract：:Recent data have shown that piperlongumine (PL), an important component of Piper longum fruits, is known to possess anti-inflammatory and vascular-protective activities. This study aimed to examine the therapeutic effects and underlying mechanisms of PL on lupus-prone MRL-Fas(lpr) mice. Female MRL-Fas(lpr) mice were i...

journal_title：Immunology letters

authors： Yao L,Chen HP,Ma Q

更新日期：2014-09-01 00:00:00

abstract：:CD24 is an extensively glycosylated membrane protein that is linked to the membrane via a glycosyl-phosphatidylinositol (GPI)-anchor. In mice, CD24 is expressed by hematopoietic and non-hematopoietic cells. CD24-/- mice do not have gross immunological defects, but detailed analysis revealed strongly reduced responses ...

journal_title：Immunology letters

authors： Bretz NP,Salnikov AV,Doberstein K,Garbi N,Kloess V,Joumaa S,Naumov I,Boon L,Moldenhauer G,Arber N,Altevogt P

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:The autoimmune regulator (AIRE) regulates autoimmunity and self-antigen expression, such as acetylcholine receptor (AchR), in the thymus. Regulatory T cells (Tregs) can down-regulate autoimmunity, but also promote tumor growth. The objective of this study was to examine the levels of AIRE, AchR, and Foxp3 ex...

journal_title：Immunology letters

authors： Liu Y,Zhang H,Zhang P,Meng F,Chen Y,Wang Y,Yao Y,Qi B

更新日期：2014-09-01 00:00:00

abstract：:Tuberculosis is an infectious disease that affects millions of people worldwide with an annual mortality rate of 1.3 million. The mechanisms contributing to the loss of balance of immune responses and progression to active tuberculosis disease are unknown. Although CD4+ and CD8+ T cells and the cytokines they produce ...

journal_title：Immunology letters

authors： Silva BDS,Trentini MM,da Costa AC,Kipnis A,Junqueira-Kipnis AP

更新日期：2014-07-01 00:00:00

abstract：:Multiple sclerosis (MS) is a debilitating neurological disorder of the central nervous system (CNS), characterized by activation and infiltration of leukocytes and dendritic cells into the CNS. In the initial phase of MS and its animal model, experimental autoimmune encephalomyelitis (EAE), peripheral macrophages infi...

journal_title：Immunology letters

authors： Jiang Z,Jiang JX,Zhang GX

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Dendritic cells (DCs) are professional antigen-presenting cells that are capable of inducing immune responses. DC-based vaccines are normally generated using a standard 5- to 7-day protocol. To shorten the DC-based vaccine production for use in cancer immunotherapy, we have developed a fast DC protocol by co...

journal_title：Immunology letters

authors： Truxova I,Pokorna K,Kloudova K,Partlova S,Spisek R,Fucikova J

更新日期：2014-07-01 00:00:00

abstract：:To investigate the in vivo role of complement component C5 it is common to compare the inflammatory response between C5-normal and C5-deficient inbred mice strains. Nevertheless, it should be expected that differences in the genetic backgrounds between those strains may affect several physiological parameters, complic...

journal_title：Immunology letters

authors： Bavia L,de Castro ÍA,Massironi SM,Isaac L

更新日期：2014-05-01 00:00:00

abstract：:In several diseases where the immune system plays an important role there has been a tremendous progress in treatment efficacy during the last decades. Based on necessary basic science these improvements are results of rapid, numerous and open-minded clinical trials where pieces of positive results step by step have b...

journal_title：Immunology letters

authors： Ludvigsson J

更新日期：2014-05-01 00:00:00

abstract：:Although several components of the microbial wall of gram-positive bacteria and fungi possess immunostimulatory properties, their pathogenetic role remains incompletely evaluated. The purpose of this study was to assess the basic immune status of patients susceptible to infections and their capability for cytokine pro...

journal_title：Immunology letters

authors： Tsigou E,Aloizos S,Myrianthefs P,Gourgiotis S,Tsakris A,Baltopoulos G

更新日期：2014-05-01 00:00:00

abstract：:Antibody direct cloning from single B cells is simple and efficient and has been successful in antibody identification of infectious diseases. However, although a recent whole-exome sequencing revealed abundant heterogeneic mutation accumulation in cancers, identification and synthesis of autoantibodies against specif...

journal_title：Immunology letters

authors： Iizuka A,Komiyama M,Oshita C,Kume A,Ashizawa T,Mitsuya K,Hayashi N,Nakasu Y,Yamaguchi K,Akiyama Y

更新日期：2014-05-01 00:00:00

abstract：:Development of active TB is accompanied by immune suppression and the underlining mechanisms have been explored extensively in recent years. MDSCs are a heterogeneous group of immature and progenitor myeloid cells with strong immunosuppressive ability for both natural and adaptive immunity. In our analysis of CD244 (2...

journal_title：Immunology letters

authors： Yang B,Wang X,Jiang J,Zhai F,Cheng X

更新日期：2014-03-01 00:00:00

abstract：:Interferon inducible transmembrane protein (IFITM) family genes have been implicated in several cellular processes such as the homotypic cell adhesion functions of IFNs and cellular anti-proliferative activities. We previously showed that the IFITM3 single nucleotide polymorphisms (SNPs) associated with susceptibility...

journal_title：Immunology letters

authors： Mo JS,Na KS,Yu JI,Chae SC

更新日期：2013-11-01 00:00:00

abstract：:Secondary lymphoid organs (SLO) are crucial structures for immune-surveillance and rapid immune responses allowing resident lymphocytes to encounter antigen-presenting cells that carry antigens from peripheral tissues. These structures develop during embryonic life through a tightly regulated process that involves int...

journal_title：Immunology letters

authors： Coles M,Veiga-Fernandes H

更新日期：2013-11-01 00:00:00

abstract：:Tumor cells have been used as the tumor antigen sources for developing cancer vaccines. Due to their low immunogenicity, tumor antigens are combined with various adjuvants to enhance immunogenicity of cancer vaccines. Among them, a natural killer T cell (NKT)-ligand, α-galactosylceramide (αGC) has been reported as a p...

journal_title：Immunology letters

authors： Hong S,Lee H,Jung K,Lee SM,Lee SJ,Jun HJ,Kim Y,Song H,Bogen B,Choi I

更新日期：2013-11-01 00:00:00

abstract：:In order to directly demonstrate the roles of CD8(+) T lymphocytes in non-human primates, in vivo depletion of the CD8(+) T cells by administration of a CD8-specific monoclonal antibody (mAb) is one of the crucial techniques. Recently, the common marmoset (Callithrix jacchus), which is classified as a New World monkey...

journal_title：Immunology letters

authors： Yoshida T,Suzuki S,Iwasaki Y,Kaneko A,Saito A,Enomoto Y,Higashino A,Watanabe A,Suzuki J,Inoue K,Kuroda T,Takada M,Ito R,Ito M,Akari H

更新日期：2013-07-01 00:00:00